Trending Topics by Specialty

GLP-1s Everywhere, Risks Under the Microscope 

• New pills and shots now reach teens, seniors, and pregnant patients as Medicare expands coverage
• Eye problems, hair loss, and bone/tendon injury draw fresh safety scrutiny
• Stopping the drugs raises heart attack risk by 22%

Kennedy Reshapes Vaccine & Antidepressant Policy 

• HHS pushes major changes to vaccine schedules and antidepressant prescribing
• Courts and FDA panels clash with efforts to cut kids' vaccine access
• Retracted studies fuel distrust in both vaccines and antidepressants

Cancer Screening Guidelines Get an Overhaul 

• Breast, colorectal, and prostate screening rules all change this year
• Blood tests and at-home kits challenge colonoscopy and biopsy
• USPSTF leadership shake-up raises credibility questions

BP & Cholesterol Treatment Gets More Aggressive

• Guidelines push earlier, harder treatment for hypertension and high cholesterol
• Lp(a) — missed by standard tests — gains recognition as a major heart risk
• New data questions today's go-to blood pressure regimens for older adults 

AI & Robots Move Into the Clinic 

• AI now predicts stroke and dementia risk and guides dialysis decisions
• Robotic surgery expands in ortho, urology, and gynecology
• Humanoid robots and AI tools pilot in dementia care and surgical training

Drug Scandals & Recalls Pile Up

• Amgen's Tavneos faces a data-manipulation scandal and possible FDA pull
• Recalls hit rosuvastatin, icosapent ethyl, and compounded weight-loss drugs
• Infant formula safety spirals after botulism outbreaks and record FDA testing

   

HER2 & Hormone-Targeted Breast Cancer

• Enhertu approved for neoadjuvant and adjuvant use in early-stage HER2-positive disease
• Vepdegestrant approved for ER-positive, ESR1-mutated advanced disease

• CDK4/6 inhibitors show added survival benefit over endocrine monotherapy

Lung Cancer Precision Therapy

• Merck-Kelun drug cuts tumor progression risk by 65% in ASCO data
• Aumolertinib shows benefit in EGFR-mutated advanced NSCLC in the AENEAS2 trial
• Zongertinib emerges as a new first-line option in HER2-mutant NSCLC

Prostate Cancer Treatment Shifts

• Darolutamide plus ADT and docetaxel improves outcomes in the ARASENS trial
• New perioperative approach called “landmark” for metastasis-free survival
• AUA releases an amendment to its advanced prostate cancer guideline

   

Pancreatic Cancer Breakthroughs

• Clinics scramble for access to Revolution Medicines’ experimental drug
• Landmark trial nearly doubles survival with a new treatment
• Germline genetic testing expands among patients with adenocarcinoma

Ivermectin Misinformation in Oncology

• Oncologists urged to proactively address questions about ivermectin and fenbendazole
• Scammers hijack a cancer doctor’s identity to promote ivermectin online
• Ivermectin-benzimidazole prescribing rises after a celebrity endorsement

Lipoprotein(a) & PCSK9/siRNA Therapies 

• Lp(a) and inflammation linked to coronary artery disease and aortic valve stenosis risk
• VESALIUS-CV trial ties evolocumab benefit to lipoprotein(a) levels
• Olezarsen vs. plozasiran compared for familial chylomicronemia syndrome 

Heart Failure Guideline & Therapy Updates 

• New Universal Definition of Heart Failure (2026) consensus document released
• Quadruple therapy shows cost offset in heart failure care
• HFpEF phenotyping via CADENCE trial reaches an “inflection point”

AFib Anticoagulation & Rhythm Control 

• ALONE-AF trial examines stopping anticoagulation after AF catheter ablation
• DOACs plus COX-2 NSAIDs linked to GI bleeding risk in atrial fibrillation
• New Jersey hospital first to use beta blocker approach for AFib

Coronary Artery Calcium Scoring Advances 

• Agatston-2.0 AI model improves risk stratification for zero Agatston scores
• CAC scoring evaluated in patients with elevated lipoprotein(a) 
• Coronary calcium scan reassessed for individual risk beyond population averages 

Hypertension Treatment Shifts 

• FDA approves first-in-class hypertension drug from AstraZeneca
• ARBs vs. calcium channel blockers compared as first-line therapy in patients 75+
• Intensive BP lowering fails to beat standard treatment on major CV events 

Thyroid Nodule & Cancer Diagnostics Advance 

• AI model validated for thyroid FNA biopsy interpretation vs. TI-RADS and specialists 
• nsPFA marks one year as a non-surgical option for benign thyroid nodules 
• ASCO and ATA issue updated guidelines for thyroid cancer and nodule management 

GLP-1/GIP Therapy Trial Expansion 

• Orforglipron outperforms dapagliflozin on HbA1c and weight (ACHIEVE-2 trial) 
• Orforglipron compared with insulin glargine in cardiovascular-risk patients (ACHIEVE-4) 
• Tirzepatide shows sustained weight maintenance in the SURMOUNT-MAINTAIN trial 

GLP-1 Access, Cost & Coverage Debate 

• Medicare finalizes landmark obesity drug coverage, though awareness lags 
• CMS unveils $50 GLP-1 prescriptions for Medicare patients 
• FDA sends 25 warning letters to telehealth companies over compounded weight-loss drug claims 

GLP-1 Safety Signals Emerge 

• Tirzepatide linked to a morbilliform drug eruption in new case report 
• Smell and taste disturbances reported among GLP-1 receptor agonist users 
• Liraglutide and semaglutide trials show NAION (ischemic optic neuropathy) incidence 

Diabetes Technology Expanding Access 

• FDA clears first over-the-counter continuous glucose monitor for children 
• First automated insulin delivery system approved for pregnancy with type 1 diabetes 
• New research aims to make insulin pump therapy safer and more reliable

Testosterone Therapy Under Scrutiny

• Testosterone therapy frequently prescribed without recommended diagnostic workup        
• HHS requests updates to testosterone therapy product labeling        
• RFK Jr. moves to lift warning labels on testosterone therapy        

Pediatric Adenotonsillectomy Safety & Recovery 

• Neuromuscular blockade shown to reduce opioid use in high-risk children undergoing adenotonsillectomy 
• FINITE trial compares recovery time for intracapsular vs. extracapsular tonsillectomy 
• Adenotonsillectomy linked to increased disease activity in pediatric-onset multiple sclerosis 

Hypoglossal Nerve Stim & GLP-1s for OSA 

• OSPREY trial evaluates proximal hypoglossal nerve stimulation for obstructive sleep apnea 
• GLP-1 receptor agonists proposed as an emerging OSA treatment option 
• Real-world analysis of 3M patients ties OSA to elevated cancer and chronic disease risk 

Thyroid Surgery Safety & Alternatives 

• Ambulatory thyroidectomy positioned as a paradigm shift in surgical safety 
• Completion vs. total thyroidectomy compared for safety in differentiated thyroid cancer 
• nsPFA marks one year as a non-surgical option for benign thyroid nodules 

Chronic Rhinosinusitis Management Scrutinized 

• Oral corticosteroids linked to adverse events in chronic rhinosinusitis with nasal polyps 
• Endoscopic sinus surgery evaluated for recurrent acute rhinosinusitis 
• Amoxicillin-clavulanate compared with amoxicillin alone for acute sinusitis 

Hearing Loss Risk Factors Identified 

• Menopause and hormone replacement therapy linked to hearing loss risk 
• Chronic kidney disease tied to increased hearing loss risk in cohort and genetic analysis 
• Low-dose aspirin examined for association with central presbycusis 

Family Medicine's Match & Workforce Crisis 

• Family medicine's residency “match problem” drives repeated coverage and concern 
• Residency fill rates continue to worsen for primary care 
• Family medicine ranked among specialties facing the greatest projected shortages by 2038 

Cancer Screening Guidelines Shift 

• ACP issues controversial new breast cancer screening guidelines 
• American Cancer Society updates colorectal cancer screening guideline 
• Long-term data show colonoscopy screening's effect on colorectal cancer incidence and mortality 

GLP-1 Side Effects & Off-Label Prescribing 

• Hair loss patterns identified and characterized among GLP-1 users 
• Unapproved weight-loss drug reportedly being prescribed despite lacking FDA approval 
• Testosterone levels shown to improve in men on GLP-1 receptor agonist therapy 

GLP-1 Discontinuation Tied to Cardiovascular Risk 

• Stopping GLP-1s linked to a 22% rise in heart attack risk 
• GLP-1s and SGLT2 inhibitors linked to nonarteritic anterior ischemic optic neuropathy 
• ACP issues living clinical guideline on pharmacologic plus lifestyle obesity treatment 

Vaccine Policy Controversy Intensifies 

• FDA advisory committee unanimously recommends its first new vaccine since 2023 
• FDA accused of blocking publication of research finding COVID and shingles vaccines safe 
• Prominent doctor reverses long-held warning about newborn vitamin K shot risk 

NP Scope of Practice & Autonomy Debate 

• 10 states now have APPs outnumbering physicians 
• Malpractice suit risk questioned amid expanding NP autonomy 
• Patient survey shows growing demand for NP access amid rising wait times 

NP Workforce Pipeline Under Strain 

• Record 93,000 nursing school applications turned away in 2025 despite rising enrollment 
• One nursing degree track sees notable enrollment decline 
• NP, PA, and RN compensation data reviewed for 2025 

GLP-1 Off-Label Use & Access Concerns 

• Unapproved weight-loss drug reportedly being prescribed despite lacking FDA approval 
• Microdosing GLP-1s raises concern among weight-loss physicians 
• Patients report ongoing trouble getting GLP-1 drugs covered by insurance 

GLP-1 Side Effects Under the Microscope 

• Hair loss patterns identified and characterized among GLP-1 users 
• GLP-1s and SGLT2 inhibitors linked to nonarteritic anterior ischemic optic neuropathy 
• Semaglutide's cardiovascular benefit tied more to dose than to weight loss achieved 

Hypertension Treatment Comparisons 

• Baxdrostat reviewed for managing uncontrolled hypertension 
• ARBs compared with ACE inhibitors for cardiovascular outcomes in atherosclerotic disease 
• Single-pill combination therapy for hypertension remains underused 

PA Scope-of-Practice Legislation & Legal Wins 

• Delaware, Virginia, and Maine governors sign laws optimizing PA scope of practice 
• Federal court recognizes PA programs as professional degree programs after student lawsuit 
• Kansas shifts from “supervision” to “collaboration” model for PA practice 

PA Compensation & Career Outlook 

• AAPA 2026 salary report shows PA pay continuing to climb amid rising demand 
• PA compensation hits $140,000 as physician shortage persists 
• New PAs advised to understand RVUs before accepting first job offers 

GLP-1 Side Effects Draw Scrutiny 

• Tirzepatide linked to a morbilliform drug eruption in new case report 
• GLP-1 receptor agonists linked to erectile dysfunction risk in men with type 2 diabetes 
• Hair loss patterns identified among GLP-1 users 

GLP-1 Access & Regulatory Actions 

• FDA seeks added safety data from Lilly on newly approved weight-loss pill 
• Unapproved weight-loss drug reportedly being prescribed despite lacking FDA clearance 
• FDA updates OTC Alli (orlistat) label to warn of kidney stone and kidney injury risk 

UTI Treatment Advances

• Zaynich approved for complicated UTIs in adults 
• Fosfomycin oral transition shows promise vs. continued IV beta-lactams for complicated UTIs 
• Fluoroquinolone and cotrimoxazole safety reviewed in older male UTI patients 

Colorectal Cancer Screening Guidelines in Flux 

• ACS updates CRC screening guideline, emphasizing blood-based and at-home stool testing 
• New blood test added to colorectal cancer screening recommendations 
• Physicians sound alarm over proposed CRC screening coverage policy changes 

Colonoscopy Effectiveness Debate 

• NordICC trial's 13-year follow-up shows no clear colonoscopy mortality signal 
• Study finds colonoscopy lowers CRC incidence but not mortality 
• Post-polypectomy colonoscopy surveillance strategies reassessed for benefit vs. burden 

GI Reimbursement & Practice Economics Under Pressure 

• Colonoscopy reimbursement cut catches ASCs off guard 
• Independent GI practices shrink as reimbursements fall 38% over a decade 
• GI workforce gaps reported to be narrowing amid economic pressures 

IBD Treatment Advances 

• Adding upadacitinib to vedolizumab shown to double endoscopic remission rates in ulcerative colitis 
• Johnson & Johnson advances IBD therapy despite a trial miss 
• GPR15L peptide identified as shaping intestinal microbiota to counteract colitis 

IBS Treatment Approaches Compared 

• Rifaximin compared with low-FODMAP diet for IBS symptom and microbiome outcomes 
• SIBO diagnostic guidelines reassessed for relevance in IBS 
• Tannin phytocomplex shown to improve IBS-D symptoms and gut-brain markers 

Alzheimer's Diagnostics & Treatment Advances 

• New blood test flags when Alzheimer's symptoms may be approaching, per AAN 2026 biomarker guidance 
• Real-world case series details lecanemab therapy outcomes outside clinical trials 
• FDA approves first non-antipsychotic drug for dementia-related agitation 

Cardiovascular Drug Management in Older Adults 

• ARBs compared with ACE inhibitors and calcium channel blockers as first-line therapy in patients 75+ 
• Intensive BP lowering fails to significantly reduce major cardiovascular events vs. standard treatment 
• DOACs plus COX-2 NSAIDs linked to GI bleeding risk in atrial fibrillation 

GLP-1 Use Expanding to Older Adults 

• Tirzepatide shows benefit for obesity in adults 65+ in SURMOUNT/SUMMIT post hoc analysis 
• New Medicare option for weight-loss drug coverage on the way 
• GLP-1 receptor agonists linked to erectile dysfunction risk in men with type 2 diabetes 

Frailty & Functional Decline Research 

• Umbrella review links frailty to multiple adverse health outcomes in older adults 
• Cognitive trajectories after major surgery tied to factors driving severe decline 
• Moving between nursing homes (“transfer trauma”) linked to higher hospitalization and mortality 

Influenza & COVID Prevention in Older Adults 

• High-dose vs. standard-dose flu vaccines compared in older adults 
• FDA approves first single-dose generic influenza treatment
• Nirmatrelvir/ritonavir effectiveness reassessed for outpatients in the Omicron era 

Polypharmacy & Medication-Related Risk 

• Anticholinergic burden linked to time-to-death in older adults 
• PPI use linked to dementia risk in population-based cohort study 
• Prescribing cascades identified as a harm risk around long-term care transitions 

Cancer Screening Guidelines in Flux

• ACS updates colorectal cancer screening guideline amid new guidance debate
• ACP issues controversial new breast cancer screening guidelines
• Two USPSTF leaders fired, raising concern about screening panel credibility

GLP-1 Safety Signals Draw Scrutiny

• Liraglutide and semaglutide linked to NAION (ischemic optic neuropathy) risk
• Short-term GLP-1 use linked to higher risk of new-onset rheumatoid arthritis
• FDA seeks added safety data from Lilly on newly approved weight-loss pill

GLP-1 Regulatory & Access Crackdown

• Americans reportedly poisoning themselves misusing semaglutide and other weight-loss drugs
• Unapproved weight-loss drug reportedly being prescribed despite lacking FDA approval
• FDA moves to exclude weight-loss drugs from a compounding pharmacy list

Dyslipidemia Guideline & Lp(a) Risk Assessment Shift

• 2026 dyslipidemia guideline pushes for earlier, lower LDL-C targets
• Combined LDL-C, Lp(a), and hsCRP assessment identifies long-term ASCVD risk
• Nonstatin lipid-lowering therapies surge in use even as statins remain dominant

Hypertension Treatment Evidence Expands

• Meta-analysis of 51 trials details long-term antihypertensive therapy effects on major CVD risk
• FDA approves first-in-class hypertension drug from AstraZeneca
• ARBs vs. calcium channel blockers compared as first-line therapy in patients 75+

Finerenone Expands Across CKD Indications

• Finerenone studied in CKD patients without diabetes
• FINE-HEART analysis examines finerenone's effect on sudden death across the cardio-kidney-metabolic spectrum
• Finerenone shown effective in CKD stages 3-4 across diabetic and non-diabetic patients

Tavneos Data Integrity Scandal Unfolds

• Medical journal retracts main study underlying Amgen's Tavneos after FDA findings
• FDA moves to rescind approval of Tavneos amid data manipulation allegations
• Japanese partner discourages Tavneos use following reported deaths

Kidney Transplant Innovation Advances

• Tegoprubart shows sustained kidney function benefit over tacrolimus in BESTOW extension data
• Blood cancer treatment enables hard-to-match kidney failure patients to receive compatible transplants
• Scientists transplant a pig liver and kidneys into a brain-dead patient in a first

IgA Nephropathy Treatment Landscape Shifts

• Iptacopan shows good 2-year results for IgA nephropathy patients
• Travere's Filspari (sparsentan) becomes first approved drug for the rare kidney disease after overcoming a Phase 3 fail
• New IgA nephropathy therapies see limited uptake in US clinical practice

Hemodialysis Technology & Access Innovation

• AI applications expand across hemodialysis clinical practice
• Bioimpedance-guided fluid management studied in hemodialysis patients
• Nephrologists successfully place tunneled dialysis catheters at bedside without fluoroscopy

Acute Kidney Injury Management in Critical Care

• BigPAK-2 tests a preventive care strategy to reduce AKI after major surgery
• oXiris filters compared with standard AN69ST filters for sepsis-associated AKI requiring CRRT
• Strategic timing of contralateral nephrectomy shown to prevent CKD after ischemic AKI

Alzheimer's Blood-Based Diagnostics Surge

• New blood test signals when Alzheimer's symptoms may be approaching
• FDA grants breakthrough designation to a urine-based Alzheimer's test
• ALZpath and Abbott sign licensing deal to develop an Alzheimer's blood test

Alzheimer's Drug Efficacy Debate Intensifies

• Review finds amyloid-targeting Alzheimer's drugs don't help patients
• Lecanemab's real-world effects on brain volume and CSF pathways detailed in new imaging data
• GSK's $700M Alector bet collapses after its Alzheimer's drug fails Phase 2

Stroke Thrombolysis & Thrombectomy Protocol Refinement

• Standard-dose tenecteplase compared with low-dose alteplase for large-vessel occlusion stroke
• Adjunctive intra-arterial alteplase studied after successful thrombectomy for acute ischemic stroke
• FDA clears new computer-assisted device for removing clots in stroke patients

Stroke Risk Prediction & Prevention Advances

• OCEANIC-STROKE trial shows asundexian prevents recurrent strokes without added bleeding risk
• AI model predicts 10-year stroke risk from a routine cardiology test
• AHA issues statement on managing ischemic stroke risk in patients with LV systolic dysfunction

Migraine Treatment Evidence Expands

• CGRP-targeted therapy evidence reviewed for vestibular migraine
• Erenumab linked to hypertension risk in real-world migraine patient registry
• Noninvasive neuromodulation trials reviewed for migraine and cluster headache

Dementia Risk Factors & Care Innovation Beyond Alzheimer's

• FDA approves first non-antipsychotic drug to treat dementia-related agitation
• Four commonly used drugs identified as potentially raising dementia risk
• UC Davis launches first long-term US study on humanoid robots in dementia care

Cesarean Delivery Technique & Risk Refinement

• New technique for uterine cesarean scar resection aims to prevent niche formation, with growing focus on long-term scar defect prevention
• Novel vaginal repair compared with laparoscopic resection for cesarean scar defects
• Predictors identified for intrapartum cesarean delivery after labor induction for suspected fetal growth restriction

Minimally Invasive Hysterectomy Techniques Compared

• vNOTES compared with total laparoscopic and conventional approaches across multiple trials and indications
• Hugo RAS and Da Vinci Xi robotic platforms compared on cost and operative time for benign hysterectomy
• Opioid-free anesthesia combined with enhanced recovery protocols studied for laparoscopic total hysterectomy

Pelvic Floor & Incontinence Surgery Advances

• Long-term outcomes compared for retropubic vs. transobturator sling procedures in recurrent stress incontinence
• A decade of colpocleisis data reviewed for outcomes and long-term patient satisfaction
• vNOTES pelvic reconstruction compared with conventional laparoscopy for high uterosacral ligament suspension

Menopause Misinformation & Hormone Therapy Safety Data

• New study offers reassuring mortality data on menopausal hormone therapy
• Hormone therapy after oophorectomy examined for breast cancer risk in BRCA carriers
• Perimenopause misinformation identified as a growing concern

Endometriosis Surgery & Treatment Advances

• Elagolix compared with dienogest for moderate-to-severe endometriosis pain in Phase III trial
• Surgical volume linked to postoperative complications in deep infiltrating endometriosis surgery
• Specialized endometriosis surgeons compared with general surgical teams on outcomes

Contraception Safety, Access & Pain Management

• Contraceptive progestogens linked to incident meningioma risk
• Same-day LARC placement reviewed for benefits and barriers in US practice
• Intrauterine anesthesia and paracervical blocks studied for IUD insertion pain

Cataract Surgery Technique & Safety Comparisons

• FLACS shows no significant safety difference versus conventional cataract surgery
• Trypan blue use linked to postoperative fungal endophthalmitis risk
• Post-cataract diplopia rates found to differ significantly by anesthetic administration type

Dropless & Premium IOL Cataract Innovation

• Dropless cataract surgery (DACS) gains traction as an evidence-based alternative to postop drops
• Newest premium IOLs reviewed for clinical use
• Monofocal-plus toric IOLs compared with monofocal implants on patient-reported outcomes

AMD Risk Factors & Emerging Treatments

• Photobiomodulation shows 12-month outcomes in dry AMD trial
• NSAID use examined as a potential AMD risk factor
• Vitamin B intake studied for association with AMD

Ocular Drug Safety & Recalls

• Massive eye drop recall highlights ongoing manufacturing and FDA inspection issues
• Novel adverse events reported with oxymetazoline eyedrop use
• Hydroxychloroquine reviewed comprehensively for ocular toxicity risk

Anti-VEGF Therapy Safety & Delivery Innovation

• Intravitreal anti-VEGF injections appear safe around cardiovascular events
• Retinal detachment risk reviewed after anti-VEGF intravitreal injection
• New delivery route explored for anti-VEGF therapy

PRP & Orthobiologic Injections for Joint Pain

• PRP shows superior outcomes over corticosteroids and NSAIDs in late-stage knee osteoarthritis
• AAPM&R issues guidance statement on platelet-rich plasma for knee osteoarthritis
• Hyaluronic acid, corticosteroids, PRP, and physical therapy compared for chronic shoulder pain

Total Hip Arthroplasty Technique Refinement

• Anterior vs. posterior approach compared for operating room timing efficiency in total hip arthroplasty
• Gluteus maximus tendon release studied for its kinematic impact during total hip arthroplasty
• Modular vs. monoblock fluted tapered stems compared in revision total hip arthroplasty

Total Knee Arthroplasty Innovation & Robotics

• Robotic TKA studied for impact of femoral pin tracker placement technique
• Digital inclinometers compared with visual estimation and computer navigation for measuring knee extension
• Patellar resurfacing's impact on patient-perceived outcomes examined in propensity-matched analysis

Shoulder Arthroplasty & Rotator Cuff Repair Advances

• Anatomic vs. reverse total shoulder arthroplasty compared for post-surgical “new normal” outcomes
• Arthroscopic vs. open Bankart repair compared for anterior shoulder instability
• Selective glenoid medialization shown to reduce acromial stress fracture risk in reverse shoulder arthroplasty

Elderly Hip Fracture Care Outcomes

• Cannulated screw fixation reviewed for nondisplaced femoral neck fractures in patients over 80
• Modified ERAS protocol shown to reduce length of stay and complications in elderly hip fracture patients
• Intraoperative death during hip fracture repair draws renewed attention

Autism Research & Treatment Controversy

• FDA withdraws GSK's approval of a drug touted as an autism treatment
• Leucovorin use scrutinized following FDA announcement tying it to autism spectrum disorder
• Prenatal acetaminophen use examined for association with autism and ADHD in sibling-matched cohorts

Pediatric Respiratory Illness Treatment Advances

• Azithromycin studied for preschoolers with wheezing in the emergency department
• Oral pentoxifylline tested as a novel adjunct therapy for pediatric community-acquired pneumonia
• GINA 2026 updates acute asthma flowcharts and inhaler guidance for children

Vaccine Policy Under Political Pressure

• HHS Secretary Kennedy fires two leaders on a preventive services task force
• Trump administration appeals court order in effort to cut vaccine recommendations for kids
• Kennedy driving a vast inquiry into vaccines despite public silence on findings

Vaccine Safety Science Scrutinized

• Elsevier retracts study tying SIDS to vaccinations
• FDA's own report finds no child deaths definitively caused by COVID vaccination
• Systematic review examines aluminum adjuvants in vaccines and potential health effects

Screen Time & Youth Mental Health Debate

• Surgeon General's office issues formal warning on screen time for children
• Child psychiatrist pushes back on the idea that smartphones are “the problem”
• Research explores design features that make screens especially engaging for kids and adults

Pediatric Food Allergy & Eating Disorder Treatment Advances

• Early egg introduction shown to help prevent food allergy in young children
• Peanut oral immunotherapy shows safety and efficiency with slow up-dosing in preschoolers
• Stanford trial shows two treatments help ARFID, a common pediatric eating disorder

• Congenital heart disease linked to increased risk of disabilities in children and adolescents regardless of severity
• Parenting stress in early childhood tied to emotional health and resilience in young adults with CHD
• AHA scientific statement finds physical activity benefits may outweigh risks in pediatric cardiomyopathies

• Ambulatory fetal heart rate and rhythm monitoring reviewed for pregnancies at risk of fetal arrhythmias
• Gestational age of onset of fetal atrial restriction linked to postnatal outcomes in hypoplastic left heart syndrome
• Isolated prenatal foramen ovale closure identified as a distinct, under-recognized clinical condition

• Vaping linked to increased risk of heart rhythm abnormalities in adolescents and young adults
• Apple Watch found to capture more pediatric arrhythmia events than traditional patch monitors
• Lawsuit alleges energy drink caused fatal caffeine-induced cardiomyopathy in a teen

• Fenestration re-creation shown to improve long-term hemodynamics after early Fontan deterioration
• Reframing medical therapy in Fontan circulation toward preserving physiologic reserve
• Single ventricle infant deaths flagged for gaps in transplant referral

• Funding pause reported to have derailed development of an artificial heart for babies
• Implantable cardioverter defibrillators studied for impact on waitlist outcomes in children with ventricular assist devices
• Six-year-old becomes South Carolina's first successful partial heart transplant recipient

• Cardiac ICU neuromonitoring shown to enable earlier recognition of arterial ischemic stroke in infants with CHD
• Pulse oximetry accuracy examined across skin pigmentation for detecting occult hypoxemia in cardiac critical care
• New biomarker-based approach proposed to distinguish myocarditis from perimyocardial syndromes in children

T1D Tech & Screening Advances

• FDA expands Tzield approval to children as young as 1 year with Stage 2 type 1 diabetes
• Dexcom G7 upgrade shown to reduce diabetes burden in youth on automated insulin delivery systems
• Inhaled insulin now FDA-approved for kids 6 and older with diabetes

Central Precocious Puberty Treatment Shifts

• Endocrine Society updates guidance on central precocious puberty evaluation and treatment
• Machine learning-based diagnostic prediction models developed for central precocious puberty in girls
• Subcutaneous 6-month vs. intramuscular 3-month leuprorelin compared for central precocious puberty treatment

Pediatric Obesity & Metabolic Risk

• Continuous glucose monitoring metrics linked to MASLD, not dysglycemia, in adolescents with obesity
• Skeletal muscle mass linked to hepatic steatosis in adolescents with overweight and obesity
• Dietary patterns linked to cardiometabolic health in children in the CORALS cohort study

GLP-1s in Adolescent Weight Management

• Combining GLP-1 receptor agonists with lifestyle therapy shown to improve adherence in adolescent weight management
• GLP-1 receptor agonists reviewed for psychiatric outcomes in adolescents
• Anti-obesity medications examined for blood pressure and chronic kidney disease implications in children

Pediatric Growth & Skeletal Disorders

• Growth hormone therapy studied after hematopoietic cell transplantation in childhood
• Non-nutritional rickets reviewed for diagnosis and management approach
• Scoliosis monitoring in Prader-Willi syndrome integrated with growth hormone therapy and pubertal transition

Pediatric MASLD & Metabolic Liver Risk

• CGM metrics linked to MASLD rather than dysglycemia in adolescents with obesity
• Niacin intake examined for association with obesity and MASLD in pediatric patients
• Relative skeletal muscle mass linked to hepatic steatosis in adolescents with overweight and obesity

Pediatric Constipation Treatment Advances

• FDA expands LINZESS to younger pediatric patients with functional constipation
• PentaSure fiber studied for safety and efficacy in managing pediatric functional constipation
• Ultrasound explored as a diagnostic tool for constipation in children

Pediatric Crohn's & IBD Treatment Advances

• FDA approves Stelara for pediatric Crohn's disease
• Early anti-TNF therapy shown effective for penetrating Crohn's complications in children
• Blood protein signature identified for non-invasive diagnosis of pediatric IBD

Pediatric Food Allergy Prevention & Management

• Early egg introduction shown to help prevent food allergy in young children
• Amino acid-based formula with synbiotics studied for cow's milk protein allergy
• Colic and excessive crying in infancy linked to later food allergy outcomes

Eosinophilic GI Disease Recognition

• Dupilumab studied against placebo for eosinophilic gastritis in the DEGAS trial
• EoE diagnosis often delayed after years of being dismissed as “just a stomach bug”
• Rumination syndrome and eosinophilic esophagitis relationship defined in children

Infant Formula Safety Scrutiny

• FDA investigates infant botulism outbreak linked to Nara Organics powdered formula
• FDA releases results from largest-ever testing of infant formula in the US
• New infant botulism outbreak puts “fancy” formulas under scrutiny

NEC Detection & Prevention Advances

• Regenerative cell and cell-free therapies advance toward clinical translation for NEC
• New noninvasive tool may allow early detection of dangerous intestinal disease in preemies
• Early probiotic exposure linked to age at NEC onset in preterm infants

Sickle Cell Gene Therapy Expansion

• FDA expands Casgevy approval to children as young as 2 with sickle cell disease
• Exa-cel studied in children with transfusion-dependent beta-thalassemia or sickle cell disease
• Fulcrum scraps its sickle cell drug program after FDA raises cancer-risk concerns

Sickle Cell Pain & Care Management

• Rilzabrutinib explored as an anti-inflammatory therapy for vaso-occlusive pain
• Early vs. delayed opioid timing compared for pediatric sickle cell vaso-occlusive crisis
• Pharmacogenomics knowledge translation studied for sickle cell pain management

Pediatric ALL Treatment Breakthroughs

• Blinatumomab successfully replaces two chemotherapy blocks in high-risk pediatric B-ALL
• Base-edited universal CD7 CAR T cells rewrite the playbook for relapsed T-cell ALL
• Carfilzomib added to induction chemotherapy for children with relapsed or refractory ALL

Pediatric HCT Complications & Conditioning

• Treosulfan-fludarabine conditioning studied in infants with severe combined immunodeficiencies
• Invasive procedures reviewed for managing complicated GI graft-versus-host disease
• Iron overload examined for its impact on HCT outcomes in nonmalignant hematological disorders

Pediatric Brain Tumor Research

• Memantine studied for preventing cognitive late effects after radiotherapy for brain tumors
• High-dose proton re-irradiation shown feasible and safe for recurrent pediatric CNS tumors
• Brain network identified linking to the deadliest form of childhood brain cancer

Pediatric Sarcoma Treatment Advances

• FL118 granted FDA rare pediatric disease and orphan drug designation for osteosarcoma
• Abemaciclib combined with irinotecan and temozolomide studied for relapsed Ewing sarcoma
• Blood-based DNA signals explored for tracking osteosarcoma in children

BPD & Respiratory Support Advances

• Sildenafil studied for safety in premature infants with severe BPD (SILDI-SAFE trial)
• Machine learning model tested for predicting bronchopulmonary dysplasia
• Extended CPAP shown to reduce intermittent hypoxemia in preterm infants

Infant Formula Safety & Litigation Surge

• Missouri jury sides with Enfamil maker Mead Johnson in preterm formula lawsuit
• FDA investigates infant botulism outbreak linked to Nara Organics powdered formula
• Formula-mixing device linked to infant's Legionnaires' disease in new report

PDA Management Strategy Shifts

• SMART-PDA pilot trial tests selective early medical treatment in extremely low gestational age infants
• Acetaminophen studied for prophylactic PDA treatment in randomized trial
• Expectant management compared with medication for PDA in preterm infants

NEC Risk & Prevention Advances

• Human-milk vs. bovine-milk-based fortifier compared for NEC risk in extremely preterm infants
• Probiotic use reassessed for NEC prevention following FDA warning actions
• New noninvasive tool explored for early detection of dangerous intestinal disease in preemies

HIE & Therapeutic Hypothermia Advances

• Parental holding during therapeutic hypothermia studied for its impact on NICU outcomes
• Hyperglycemia management practices reviewed in neonatal encephalopathy (THiNE study)
• Timing of echocardiography examined for hemodynamic assessment in neonatal HIE

Delivery Room Resuscitation Practice Variation

• Stabilization and resuscitation practices found to vary widely across 12 neonatal networks
• Bag-and-mask ventilation at birth linked to specific mortality risk factors
• Delayed cord clamping paired with immediate kangaroo care studied for oxygen saturation effects

Pediatric Autism Treatment & Mechanism Research        

• AST-001 shows 52-week safety and efficacy data in children with autism spectrum disorder        
• Pimavanserin studied for irritability in children and adolescents with autism in a Phase 2 trial        
• A “3-hit” metabolic signaling model proposed to explain core autism symptoms

Vertebral Body Tethering & Scoliosis Care

• VBT explained as an emerging option, candidate criteria outlined
• Fusion risk factors for junctional kyphosis identified in AIS
• Early intervention tied to better long-term outcomes

Pediatric Spine Surgery Innovation

• 32,000+ surgeries analyzed for who benefits from flap reconstruction
• Awake spine surgery cuts general anesthesia risk in lumbar procedures
• Multidisciplinary approach boosts safety in complex spinal cases

New ADHD Drug Pipeline & Dosing Evidence

• Centanafadine shown effective for ADHD in adolescents in randomized trial
• FDA declines to approve Cingulate's ADHD treatment over manufacturing issues
• Network meta-analysis maps optimal stimulant dose ranges for children and adolescents with ADHD

ADHD Diagnosis & Long-Term Outcomes

• Age at first ADHD diagnosis linked to later educational outcomes
• Childhood ADHD traits linked to societal exclusion and midlife psychological distress
• Methylphenidate examined for its effect on physical growth in children with ADHD

Autism Treatment Pipeline & Diagnosis Debate

• AST-001 shows 52-week safety and efficacy data in children with autism
• Pimavanserin studied for irritability in autism in Phase 2 trial
• FDA withdraws GSK's approval of a drug touted as an autism treatment

Antidepressant Policy & Safety Controversy

• HHS Secretary Kennedy's push to curb antidepressants shakes psychiatry
• ADAA26 issues three new recommendations for managing antidepressants
• FDA recalls a popular antidepressant over possible carcinogen risk

Screen Time, Social Media & AI in Youth Mental Health

• Surgeon General's office issues formal warning on screen time for children
• Two hours of daily social media linked to teen depression
• AI chatbot use and disclosure studied among adolescents seeking mental health support

Youth Suicide & Depression Risk Factors

• Summer heat linked to increased risk of death by suicide in youth
• New drug combination studied for preventing death by suicide
• Pubertal timing and tempo linked to depression risk in adolescent boys and girls

Severe Asthma Biologics & Guideline Updates

• FDA approves BREZTRI Aerosphere for asthma maintenance treatment in patients 12 and older
• GB-0895 adjunctive therapy trial now recruiting for severe pediatric asthma
• GINA 2026 updates acute flowcharts and inhaler guidance for children

Pediatric Mechanical Ventilation Practice Advances

• PRoVENT-PED study delivers first results on ventilation management and outcomes in children
• Cuffed vs. uncuffed endotracheal tubes compared for pediatric intubation
• Neuromuscular blocker use questioned for routine pediatric intubation

Pediatric Pneumonia Diagnosis & Management

• Point-of-care lung ultrasound explored for diagnosing pneumonia in pediatric patients
• New study helps explain why pneumococcal pneumonia is making kids sicker
• Azithromycin studied for preschoolers with wheezing in the emergency department

Cystic Fibrosis Treatment Advances

• Elexacaftor/tezacaftor/ivacaftor shows 96-week interim safety and efficacy in children 2 and older
• Synergistic mucociliary clearance therapy explored using beta-adrenergic plus cholinergic agonists
• Parent caregivers' lived experiences studied to identify unmet needs in cystic fibrosis care

Pediatric Respiratory Monitoring & Oxygenation Advances

• OxyKids trial tests oxygen saturation thresholds in children with acute respiratory distress
• Noninvasive oxygenation monitoring validated for persistent pulmonary hypertension of the newborn
• Nasal interface and pressure choices compared across a decade of NICU data

Youth Vaping & Tobacco Policy Shifts

• National Youth Tobacco Survey tracks vaping and tobacco use trends among students
• Youth vaping flagged as an under-recognized risk behavior in pediatric emergency care
• UK lawmakers approve lifetime smoking ban for today's under-18s

Kennedy's Antidepressant Deprescribing Push

• HHS launches MAHA Action Plan to curb psychiatric overprescribing
• Kennedy starts a push to help Americans quit antidepressants
• Top psychiatrists call for greater focus on ceasing medication amid the pressure

Antidepressant Safety & Prescribing Debate

• Antidepressant recalled over presence of a potentially cancer-causing impurity
• ADAA26 issues three new recommendations for managing antidepressants
• “Chemical imbalance” framing for depression challenged as a myth

Novel Depression Treatment Pipeline

• Pramipexole studied as a dopamine agonist for anhedonic depression
• Ketamine infusions shown to rapidly reduce suicidal and depressive symptoms
• Psychedelic drugmaker Definium surges on depression drug trial success

Schizophrenia & Psychosis Treatment Advances

• Buspirone combined with clozapine studied for cognitive function in schizophrenia
• FDA pauses Newron's Phase 3 schizophrenia study after a patient death
• Cannabis-associated psychosis proposed as a distinct clinical condition

Psychiatric Diagnosis Reliability Debate

• New DSM aims to help clinicians diagnose more holistically
• Study casts doubt on the reliability of standard mental health diagnostic interviews
• Framework proposing just five “families” of psychiatric disorders draws attention

GLP-1s & Metabolic Drugs Enter Psychiatric Practice

• Once-weekly semaglutide studied against placebo for alcohol use disorder with comorbid obesity
• GLP-1 receptor agonist use linked to psychiatric worsening risk in treated depression
• SGLT2 inhibitors explored for lowering dementia risk in patients with mental illness

Critical Care Airway Management & Intubation Safety

• MASCAN score proposed to bring precision to airway management assessment
• Rocuronium compared with succinylcholine for rapid sequence intubation awareness and paralysis risk
• Preoxygenation strategies systematically reviewed for intubating critically ill patients

Mechanical Ventilation Strategy Refinement

• Higher vs. lower PEEP levels compared for mortality impact in ventilated sepsis patients
• Risk-adjusted mechanical-power score proposed to reframe ventilator-induced lung injury risk
• Inhaled vs. intravenous sedation compared in ARDS patients

Severe Asthma Biologics Advance

• Tezepelumab shows one-year clinical remission in severe asthma (TERESA study)
• Benralizumab studied for clinical remission in severe eosinophilic asthma
• CHRONICLE study tracks real-world effects of asthma biologics on blood eosinophil levels

COPD Outcomes & Treatment Advances

• Triple therapy shows real-world long-term outcomes after COPD exacerbation hospitalization
• Private equity-owned hospitals linked to worse outcomes for COPD patients
• Non-pharmacological breathlessness intervention service tested for severe COPD

Pulmonary Fibrosis Treatment & Detection Advances

• Nerandomilast data released from the full FIBRONEER-IPF trial follow-up
• Corticosteroids reviewed for treating acute IPF exacerbations
• CARDIA Lung Study tracks lung function trajectories tied to interstitial lung abnormalities

OSA Treatment Innovation

• OSPREY study tests proximal hypoglossal nerve stimulation for obstructive sleep apnea
• Atomoxetine plus oxybutynin studied in randomized trial for OSA
• Hypoxic burden examined in OSA patients on hypoglossal nerve stimulation

PRP & Orthobiologic Injections for Joint Pain

• AAPM&R issues guidance statement on platelet-rich plasma for knee osteoarthritis
• Adipose-derived and bone marrow aspirate concentrate injections reviewed for osteoarthritis
• Hyaluronic acid, corticosteroids, PRP, and physical therapy compared for chronic shoulder pain

Low Back Pain Treatment Approaches Compared

• Prolotherapy compared with epidural steroid injections for lumbar pain with leg pain
• Antibiotics studied for chronic low back pain with disc herniation
• TENS, electrical muscle stimulation, exercise, and heat compared for back pain relief

Radiofrequency Ablation for Facet-Mediated Back Pain

• Thermal radiofrequency ablation compared with corticosteroid injections for facet-mediated chronic low back pain
• Radiofrequency ablation reviewed for managing chronic axial spinal pain of facet joint origin
• Radiofrequency ablation explored as an option for younger back pain patients

Spinal Cord Stimulation Advances & Complications

• Spinal cord stimulation studied for upper limb motor function in chronic post-stroke hemiparesis
• Opioid use changes reviewed following spinal cord stimulation
• Anchoring technique reviewed to address spinal cord stimulator displacement

Stroke Motor Recovery Rehabilitation Advances

• Virtual reality and mirror therapy compared for upper extremity motor recovery after stroke
• FLOW trial tests fluoxetine combined with exercise for motor recovery after stroke
• Paired vagus nerve stimulation studied for upper and lower extremity recovery in chronic stroke

GLP-1 Effects on Musculoskeletal Health

• GLP-1 drugs like Ozempic linked to increased bone and tendon injury risk
• FDA fast-tracks an intra-articular GLP-1RA for knee osteoarthritis
• Body composition changes tracked in GLP-1 patients undergoing cardiac rehabilitation

JAK Inhibitors & Biologics Reshape RA Treatment

• Upadacitinib and TNF inhibitors compared for persistence and effectiveness using Canadian and Swiss registry data
• Sarilumab compared with JAK inhibitors in late- and younger-onset RA
• Real-world evidence compares safety and efficacy across JAK inhibitors in rheumatology practice

RA Prevention & Early Treatment Strategy Shifts

• Abatacept compared with hydroxychloroquine for preventing RA in palindromic rheumatism
• VACIMRA trial data show a one-month methotrexate delay affects RA outcomes
• Short-term GLP-1 receptor agonist use linked to higher risk of new-onset RA

CAR-T & Novel Therapies Transform Lupus Care

• CAR-T cell therapy continues to surprise autoimmunity researchers five years after its lupus breakthrough
• Anifrolumab explored in a novel use for a novel disease presentation
• Higher weight-based hydroxychloroquine dosing linked to lower SLE flare risk

Novel Knee OA Treatments Emerge

• Genicular nerve radiofrequency treatment reviewed for chronic knee osteoarthritis pain
• FDA fast-tracks an intra-articular GLP-1RA for knee osteoarthritis
• Low-dose radiation therapy studied as an option for osteoarthritis

Tavneos Scandal Rocks ANCA Vasculitis Treatment

• Medical journal retracts main study underlying Amgen's Tavneos
• FDA alleges manipulated data supported the drug's approval
• Tavneos tied to 20 deaths in Japan, prompting partner pushback

Gout Treatment Advances

• Firsekibart compared with compound betamethasone for frequent gout flares
• Normal serum uric acid gout flagged as an underrecognized, challenging condition
• Gout linked to increased ischemic stroke risk in patients with atrial fibrillation

Kidney Transplant Technique & Outcomes Advances

• Tegoprubart shows sustained kidney function benefit over tacrolimus in BESTOW extension data
• Single-kidney transplant using a discarded partner kidney compared with dual kidney transplantation
• Finerenone explored as third-line therapy for persistent proteinuria in diabetic kidney transplant recipients

Kidney Transplant Access & Innovation

• Blood cancer treatment enables hard-to-match kidney failure patients to receive compatible transplants
• Scientists transplant a pig liver and kidneys into a brain-dead patient in a first
• New treatment lets three transplant patients halt anti-rejection drugs entirely

Pediatric Heart Transplant Access & Innovation

• Hypoplastic left heart syndrome patient thrives after a 419-day wait for a new heart
• Six-year-old becomes South Carolina's first successful partial heart transplant recipient
• Funding pause reported to have derailed development of an artificial heart for babies

Pediatric Stem Cell Transplant for Nonmalignant Disease

• Nonmyeloablative HLA-identical sibling transplant studied for sickle cell disease in children
• Treosulfan-fludarabine conditioning studied in infants with severe combined immunodeficiencies
• Second allogeneic HCT after graft failure shown effective in children with hemoglobinopathies

BPH Treatment Technology Shootout

• Rezum and UroLift compared for 3-year reintervention rates
• Aquablation compared with AEEP for evolving BPH surgical landscape
• iTind reviewed for sexual and urinary outcomes in BPH treatment

Prostate Cancer Screening Debate Intensifies

• Renaming lowest-risk prostate “cancer” proposed to potentially save lives
• New NCCN patient guidelines say prostate cancer screening benefits outweigh harms
• Updated AUA/ASTRO guideline addresses clinically localized prostate cancer management

Prostate Cancer Diagnostic Innovation

• Liquid biopsy and PSMA-PET explored as alternatives to avoid unnecessary prostate biopsies
• PSA persistence reassessed as a risk factor in the PSMA PET era after radical prostatectomy
• Risk prediction tools compared for performance across different patient populations

Kidney Stone Treatment Technique Innovation

• FANS compared with mPCNL for treating 2-3 cm upper urinary tract stones
• New biomedical engineering-powered kidney stone treatment device receives FDA approval
• Needle-perc technique compared with retrograde intrarenal surgery for lower pole renal stones

Robotic & AI-Assisted Urologic Surgery Advances

• Teleoperated humanoid robots used to perform live surgery in a world first
• KangDuo-SR-2000 robotic system studied for radical prostatectomy outcomes
• AI's growing role in urology training and practice examined

Men's Sexual Health Device & Treatment Advances

• Coloplast's next-generation inflatable penile prosthesis approved by the FDA
• GLP-1 receptor agonist use linked to erectile dysfunction risk in men with type 2 diabetes
• FDA says Amazon violated federal regulations selling unapproved penile creams

Gender Pay Gap in Medicine

• Women doctors paid roughly $20,000 less than male doctors, new data show
• Gender disparities identified in interventional pain medicine representation, leadership, and pay
• Pediatrics issues a policy statement addressing gender pay equity

Burnout & Attrition Driving Women Out of Medicine

• National survey explores why physicians are leaving clinical practice early
• Physician loneliness identified as a driver of women leaving medicine
• Sense of belonging linked to lower burnout rates among physicians

Pregnancy & Parenthood Support Gaps in Training

• Parental support package shown to dramatically reduce burnout in child-bearing physician trainees
• Obstetric complications linked to workplace conditions for female surgeons
• Mass General Brigham surgeon highlighted for making surgical training safer during pregnancy

Discrimination & Safety Barriers for Women in Medicine

• SSM doctor wins $6.8M verdict in sex discrimination lawsuit against health system
• New data reveal ongoing safety risks for female clinicians in urology clinics
• Systemic barriers identified for women in advanced endoscopy training

Representation Gaps in Research & Leadership

• NIH investigator trends tracked by sex, race, ethnicity, and disability status
• Gender gap in medical research participation and leadership examined
• Pathology workforce diversity assessed across the specialty